Comprehensive Clinical Evaluation

A 12-week, randomised, double-blind, placebo-controlled clinical trial investigating cognitive processing speed, sleep, libido, skin hydration, skin barrier function, wrinkle appearance and hair health.

The study includes objective clinical assessments and validated questionnaires, providing a structured approach to evaluating a range of health and wellbeing measures.

Results from the randomised controlled trial are currently being analysed.

Exploratory Results from The Circle Pilot Study

Separately from the randomised controlled trial, biological age assessments were conducted in a pilot cohort of participants from The Circle.

The pilot analysis identified statistically significant changes in several DNA methylation-based biological age estimates, including:

• 5.2 years lower HRS InCHPhenoAge estimate
• 4.1 years lower Robust PhenoAge estimate
• 3.0 years lower Robust Horvath estimate
• 2.4 years lower GrimAge2 Tuned estimate

These preliminary findings are exploratory and do not establish that Advanced ID reduces biological age. The pilot study was not placebo-controlled, and the results should not be interpreted as evidence of a treatment effect.

Placebo-controlled biological age findings from the randomised controlled trial are awaited.

Real-World Healthspan Monitoring

The Circle is a 12-week observational programme involving 80 participants, created to explore the Advanced ID experience in an everyday setting, outside a controlled clinical trial.

The programme combines WHOOP biometric monitoring with structured participant questionnaires covering energy, sleep, recovery, cognitive function, skin, hair and nail health, and sexual wellbeing.

Responses are brought together in an overall ID Score, providing a consistent way to track participants' self-reported experiences throughout the programme.

What Participants Reported Over 12 Weeks

• 94% recorded an improvement in their overall ID Score
• 92% reported improvements in energy
• 91% reported improvements in sleep
• 91% reported improvements in skin, hair and nail health
• 86% reported improvements in cognitive function

These results reflect changes reported by participants in an observational programme. Without a placebo-controlled comparison, they cannot establish that Advanced ID caused the reported improvements.

Investigating Skin Responses to UV Exposure

An ongoing clinical study investigating the effects of an oral nutritional intervention on Minimal Erythema Dose (MED), an established measure used in photobiology research to assess skin responses to ultraviolet radiation.

The study forms part of our wider research programme exploring skin health through objective clinical measurements.

Results are pending.